diff --git a/src/sql/workbench/contrib/notebook/browser/notebookActions.ts b/src/sql/workbench/contrib/notebook/browser/notebookActions.ts
index c85d0a37ca..e6c64290d0 100644
--- a/src/sql/workbench/contrib/notebook/browser/notebookActions.ts
+++ b/src/sql/workbench/contrib/notebook/browser/notebookActions.ts
@@ -37,6 +37,7 @@ import { IAdsTelemetryService } from 'sql/platform/telemetry/common/telemetry';
 import { IQuickInputService } from 'vs/platform/quickinput/common/quickInput';
 import { KernelsLanguage } from 'sql/workbench/services/notebook/common/notebookConstants';
 import { INotebookViews } from 'sql/workbench/services/notebook/browser/notebookViews/notebookViews';
+import { Schemas } from 'vs/base/common/network';
 
 const msgLoading = localize('loading', "Loading kernels...");
 export const msgChanging = localize('changing', "Changing kernel...");
@@ -53,6 +54,7 @@ const maskedIconClass = 'masked-icon';
 export const kernelNotSupported: string = localize('kernelNotSupported', "This notebook cannot run with parameters as the kernel is not supported. Please use the supported kernels and format. [Learn more](https://docs.microsoft.com/sql/azure-data-studio/notebooks/notebooks-parameterization).");
 export const noParameterCell: string = localize('noParametersCell', "This notebook cannot run with parameters until a parameter cell is added. [Learn more](https://docs.microsoft.com/sql/azure-data-studio/notebooks/notebooks-parameterization).");
 export const noParametersInCell: string = localize('noParametersInCell', "This notebook cannot run with parameters until there are parameters added to the parameter cell. [Learn more](https://docs.microsoft.com/sql/azure-data-studio/notebooks/notebooks-parameterization).");
+export const untitledNotSupported: string = localize('untitledNotSupported', "Run with parameters is not supported for Untitled notebooks. Please save the notebook before continuing. [Learn more](https://docs.microsoft.com/sql/azure-data-studio/notebooks/notebooks-parameterization).");
 
 // Action to add a cell to notebook based on cell type(code/markdown).
 export class AddCellAction extends Action {
@@ -448,6 +450,14 @@ export class RunParametersAction extends TooltipFromLabelAction {
 	 * with injected parameters value from the QuickInput
 	*/
 	public override async run(context: URI): Promise<void> {
+		if (context.scheme === Schemas.untitled) {
+			// Run with parameters is not supported for untitled notebooks
+			this.notificationService.notify({
+				severity: Severity.Info,
+				message: untitledNotSupported,
+			});
+			return;
+		}
 		const editor = this._notebookService.findNotebookEditor(context);
 		// Only run action for kernels that are supported (Python, PySpark, PowerShell)
 		let supportedKernels: string[] = [KernelsLanguage.Python, KernelsLanguage.PowerShell];
diff --git a/src/sql/workbench/contrib/notebook/test/browser/notebookActions.test.ts b/src/sql/workbench/contrib/notebook/test/browser/notebookActions.test.ts
index 3492de4cfe..82726a8b34 100644
--- a/src/sql/workbench/contrib/notebook/test/browser/notebookActions.test.ts
+++ b/src/sql/workbench/contrib/notebook/test/browser/notebookActions.test.ts
@@ -7,7 +7,7 @@ import * as assert from 'assert';
 import * as azdata from 'azdata';
 import * as sinon from 'sinon';
 import { TestConfigurationService } from 'sql/platform/connection/test/common/testConfigurationService';
-import { AddCellAction, ClearAllOutputsAction, CollapseCellsAction, CreateNotebookViewAction, DashboardViewAction, kernelNotSupported, KernelsDropdown, msgChanging, NewNotebookAction, noKernelName, noParameterCell, noParametersInCell, NotebookViewAction, NotebookViewsActionProvider, RunAllCellsAction, RunParametersAction, TrustedAction } from 'sql/workbench/contrib/notebook/browser/notebookActions';
+import { AddCellAction, ClearAllOutputsAction, CollapseCellsAction, CreateNotebookViewAction, DashboardViewAction, kernelNotSupported, KernelsDropdown, msgChanging, NewNotebookAction, noKernelName, noParameterCell, noParametersInCell, NotebookViewAction, NotebookViewsActionProvider, RunAllCellsAction, RunParametersAction, TrustedAction, untitledNotSupported } from 'sql/workbench/contrib/notebook/browser/notebookActions';
 import { ClientSessionStub, ContextViewProviderStub, NotebookComponentStub, NotebookModelStub, NotebookServiceStub, NotebookViewsStub, NotebookViewStub } from 'sql/workbench/contrib/notebook/test/stubs';
 import { NotebookEditorStub } from 'sql/workbench/contrib/notebook/test/testCommon';
 import { ICellModel, INotebookModel, ViewMode } from 'sql/workbench/services/notebook/browser/models/modelInterfaces';
@@ -120,7 +120,7 @@ suite('Notebook Actions', function (): void {
 
 	let mockNotebookEditor: TypeMoq.Mock<INotebookEditor>;
 	let mockNotebookService: TypeMoq.Mock<INotebookService>;
-	const testUri = URI.parse('untitled');
+	const testUri = URI.parse('file://a/b/c/test.ipynb');
 	let testNotebookModel = new TestNotebookModel();
 
 	suiteSetup(function (): void {
@@ -536,6 +536,51 @@ suite('Notebook Actions', function (): void {
 		assert.strictEqual(actualMsg, expectedMsg);
 	});
 
+	test('Should inform user that run with parameters is not supported for untitled notebooks', async function (): Promise<void> {
+		// Kernels that are supported (Python, PySpark, PowerShell)
+		const untitledUri = URI.parse('untitled:Notebook-0');
+		const testContents: azdata.nb.INotebookContents = {
+			cells: [{
+				cell_type: CellTypes.Code,
+				source: ['x=2.0\n', 'y=5.0'],
+				metadata: { language: 'python' },
+				execution_count: 1
+			}],
+			metadata: {
+				kernelspec: {
+					name: 'python',
+					language: 'python',
+					display_name: 'Python 3'
+				}
+			},
+			nbformat: NBFORMAT,
+			nbformat_minor: NBFORMAT_MINOR
+		};
+		let expectedMsg: string = untitledNotSupported;
+
+		let actualMsg: string;
+		let mockNotification = TypeMoq.Mock.ofType<INotificationService>(TestNotificationService);
+		mockNotification.setup(n => n.notify(TypeMoq.It.isAny())).returns(notification => {
+			actualMsg = notification.message;
+			return undefined;
+		});
+
+		let quickInputService = new MockQuickInputService;
+		let testLanguageInfo: azdata.nb.ILanguageInfo = {
+			name: 'python',
+		};
+		let mockNotebookModel = new NotebookModelStub(testLanguageInfo, undefined, testContents);
+
+		let action = new RunParametersAction('TestId', true, untitledUri, quickInputService, mockNotebookService.object, mockNotification.object);
+
+		mockNotebookEditor.setup(x => x.model).returns(() => mockNotebookModel);
+
+		// Run Parameters Action
+		await action.run(untitledUri);
+
+		assert.strictEqual(actualMsg, expectedMsg);
+	});
+
 	test('notebookViewsActionProvider', async () => {
 		const testGuid = '1';
 		const testName = 'Notebook-0';